Synthesis and Characterization of Magnetic Molecularly Imprinted Polymer for the Monitoring of Amoxicillin in Real Samples Using the Chromatographic Method

Amoxicillin (AMX) is an antibiotic frequently used for the treatment of bacterial disorders and respiratory problems in both humans animals. This work aims to synthesize a molecularly imprinted superparamagnetic polymer (SP-MIP) with core-shell structure selective detection AMX real samples. Magnetite nanoparticles (SNP) were prepared by polyol method, coated silica, functionalized silane groups. The polymerization process was executed using free-radical precipitation method. Thermogravimetric analysis (TGA) evaluate thermal stability synthesized materials. results obtained from N2 adsorption desorption analyses showed that surface area SP-MIP (19.8 m2/g) higher than non-molecularly (SP-NIP—9.24 m2/g). optimized SP-NIP followed SIP-type behavior, constant KS 0.01176, 1/n 1.73. selectivity tests highly presence other molecules. Finally, recovery analysis, application determining samples tap water, river drugs HPLC yielded mean value 94.3%.